2019/9/4 – CRI Report

Blockchain Adoption In Automotive Industry

admin — Sat, 12 Sep 2020 05:18:08 +0000

Over the last few years, breakthroughs in blockchain tech have infused some of the most revolutionary and exceptional upgrades to processes across various industries. This growing impact of blockchain on different industries has risen the confidence of stakeholders and in turn egging them on to focus on use cases that seemed complex before. Spotting the potential of blockchain and opportunities it opens up, legacy auto majors have begun adopting this emerging tech to remain competitive as well as relevant in future market scenarios.
Current blockchain solutions for the automotive industry range from mobility services to data monetization. Among these solutions, BC seeks to answer challenges posed in the insurance, the marketplace economy as well as the vehicle autonomy spaces to further bridge the ever narrowing distance between consumers and producers.
This report includes a comprehensive analysis of the adoption of BC tech in the auto industry and also highlights the major trends and opportunities across the ecosystem.
Blockchain Impact and Adoption Trend Analysis
This section of the report identifies the segments of the auto industry that hold a key role in the adoption and roll out of blockchain tech. Included in this section is also a summary of the critical details of the current industry structure and ecosystem and the foundational elements with respect to blockchain tech, applicable blockchain types and their uses or business case as well as a detailed analysis of the impact of blockchain on the auto industry.
This section along with highlighting the use cases and applications of blockchain in the auto industry also lists the benefits, implementation challenges, and the expected timeline for blockchain adoption in the auto industry. Moreover, this section of the report also explores future revenue and business models in light of the opportunities that are anticipated to arise from blockchain adoption.

Automotive Blockchain Services
This section of the report identifies different blockchain-enabled automotive solutions that are or can be realized – mobility services, supply chain services, electric vehicle charging, vehicle autonomy, data monetization, and data history, insurance, marketplace, loyalty, and other solutions – whilst providing detailed info. on the space. The information in this section encompasses an overview of the industry, details of the startup ecosystem, leading startups and their offerings, case studies, and revenue models. This section also lists and profiles startups and technology companies creating a niche and leaving a mark on the industry. Some of the top companies focused on delivering automotive-linked services through blockchain-enabled solutions have also been profiled briefly in this section.

The post Blockchain Adoption In Automotive Industry first appeared on CRI Report.

Investigation Report on China’s Recombinant Human Thrombopoietin Market, 2019-2023

admin — Wed, 04 Sep 2019 05:31:10 +0000

Description
In recent years, the incidence of thrombopenia in China keeps increasing. Thrombopenia is often seen in hematologic diseases such as primary immune thrombopenia, leukemia and aplastic anemia as well as in connective tissue diseases, liver diseases and tumor chemotherapy. Thrombopenia may also be congenital or drug-induced. Primary immune thrombopenia is a clinically common hemorrhagic disease, accounting for 1/3 of hemorrhagic diseases. The annual incidence of primary immune thrombopenia is 5/100,000 to 10/100,000. The number of patients with thrombopenia in China is increasing by over 100,000 every year. Research shows that 20% to 30% of patients receiving chemotherapy have obvious thrombopenia. The incidence of thrombopenia is 81.80% among patients receiving single-agent carboplatin chemotherapy, 58.20% among patients receiving carboplatin combination chemotherapy, 64.40% among patients receiving gemcitabine chemotherapy and 59.30% among patients receiving paclitaxel chemotherapy.
Using thrombopoietin such as Recombinant Human Thrombopoietin is one of the ways to treat thrombopenia. In 2005, Recombinant Human Thrombopoietin by Shenyang Sunshine Pharmaceutical Co., Ltd. (trade name: TPIAO) was approved to be sold in China. By Aug. 2019, it is the only approved Recombinant Human Thrombopoietin product on the Chinese market.
In China, Recombinant Human Thrombopoietin applies to the treatment of patients with thrombopenia (platelet count < 50×109/L) caused by solid tumor chemotherapy when doctors regard it necessary to increase platelet count. It is also used to assist the treatment of patients who have idiopathic thrombocytopenic purpura with platelet count below 20×109/L when glucocorticoids do not work. It is only applied to patients with thrombopenia and patients facing the increasing risk of bleeding. It is not used to increase platelet count to the normal level.
According to CRI’s market survey, the sales value of Recombinant Human Thrombopoietin kept rising after the drug was launched in China. In 2017, it reached CNY 523 million, representing a CAGR of 27.90% from 2013 to 2017.
CRI expects that as the number of patients with thrombopenia increases in China, the demand for Recombinant Human Thrombopoietin will also increase. Considering the high growth rate of the Recombinant Human Thrombopoietin market, Recombinant Human Thrombopoietin products by other enterprises will probably be approved to be launched in China in the next few years.

The post Investigation Report on China’s Recombinant Human Thrombopoietin Market, 2019-2023 first appeared on CRI Report.

Investigation Report on China’s Prothrombin Complex Concentrate (PCC) Market, 2019-2023

admin — Wed, 04 Sep 2019 05:31:10 +0000

Description
Hemophilia is an X-linked recessive hemorrhagic disease. It is classified into hemophilia A, a deficiency in clotting factor VIII and hemophilia B, a deficiency in clotting factor IX. Both hemophilia A and hemophilia B are caused by gene mutations.
There is no racial or regional difference in the incidence of hemophilia. In the male population, the incidence of hemophilia A is about 1/5,000, and the incidence of hemophilia B is about 1/25,000. Of all hemophiliacs, patients with hemophilia A account for 80% to 85% and patients with hemophilia B account for 15% to 20%. Hemophilia is rarely seen in women. Because of economic factors and other factors, the incidences of hemophilia vary greatly from one country to another and even vary greatly from one period to another in the same country. It is estimated that there were more than 100,000 hemophiliacs in China at the end of 2018. And most of them failed to receive timely treatment because they had no ability to pay.
Prothrombin complex concentrate (PCC) is made from healthy human plasma. Made up of clotting factors II, VII, IX and X, PCC has been on the global market for more than 50 years. In earlier years, PCC was used to treat hemophilia B. In recent years, with the development of medical technologies and the accumulation of clinical experience, the indications and demand for PCC are expanding.
In China, PCC has been approved to:
(1) prevent and treat bleeding caused by the deficiency in clotting factors II, VII, IX or X, for example, the bleeding caused by hemophilia B, severe liver diseases (acute severe hepatitis, cirrhosis, etc.), disseminated intravascular coagulation (DIC) and surgeries;
(2) reverse the bleeding induced by anticoagulants such as coumarins and indandione;
(3) prevent and treat the bleeding in patients who have hemophilia A and have produced inhibitory antibodies against clotting factor VIII;
(4) treat newborn babies who have secondary vitamin K deficiency and those who take broad-spectrum antibiotics in severe bleeding or preoperative preparation; and
(5) treat diphacinone sodium salt poisoning.
According to CRI’s market survey, the market size of PCC kept rising after the drug was launched in China. In 2017, it reached about CNY 70 million, representing a CAGR of about 25.90% from 2013 to 2017. PCC is only sold in the dosage form of injection in China. As PCC production requires high technologies, China prohibits the import of PCC and there are few manufacturers of PCC in China, China’s PCC market is highly concentrated with CR5 of more than 90%. In 2017, Hualan Biological Engineering Inc. took up the largest share of China’s PCC market. Its market share was about 55% by sales value and about 63% by sales volume. The other major market players were Shandong Taibang Biological Products Co., Ltd., China Meheco Xinxing Pharma Co., Ltd., etc.
CRI expects that as the numbers of hemophiliacs and patients with severe liver diseases continue to increase and medical expenses become more affordable to Chinese people with China’s economic growth, China’s PCC market will have huge growth potential from 2019 to 2023. The high profit rate of PCC is attracting more competitors to the market. For example, in Aug. 2019, Boya Bio-pharmaceutical Group Co., Ltd. announced that its PCC was under the priority review of the Center for Drug Evaluation of China’s National Medical Products Administration (NMPA CDE) and was expected to be launched in China in one to two years.

Topics Covered:
– Incidences of hemophilia and severe liver diseases in China
– Supply of and demand for PCC in China
– Competition on China’s PCC market
– Prices of PCC in China
– Major factors influencing the development of China’s PCC market
– Prospect of China’s PCC market from 2019 to 2023

The post Investigation Report on China’s Prothrombin Complex Concentrate (PCC) Market, 2019-2023 first appeared on CRI Report.

Investigation Report on China’s Finasteride Market, 2019-2023

admin — Wed, 04 Sep 2019 05:31:10 +0000

Description
The prostate is a male-specific gonadal organ. Benign prostatic hyperplasia (BPH) is the most common benign disease among the causes of urination disorder in middle-aged and elderly men. Epidemiologically, the incidence of BPH increases with age. BPH usually occurs after the age of 40. The incidence in men aged above 60 is higher than 50% and the incidence in men aged above 80 is 83%. Like histologic appearance, symptoms such as dysuria also increase with age. Patients with BPH account for 8% to 11% of urological inpatients, with incidence second only to that of lithangiuria. As the Chinese population ages, BPH will affect the health of more elderly people.
Finasteride is a 4-nitrosteroid hormone compound, a specific type II 5α-reductase inhibitor developed by U.S. company MSD. Since Jun. 1992 when it was approved by the FDA to be sold under trade name Proscar, it has been registered and launched in over 100 countries and regions around the world. After MSD launched Finasteride in China, many Chinese pharmaceutical companies began to develop generic Finasteride. In China, Finasteride is used to treat and control BPH and prevent urinary system events, reduce the risk of acute urinary retention and reduce the risks of transurethral resection of the prostate (TURP) and prostatectomy.
According to CRI’s market survey, in 2003, Zhejiang Xianju Pharmaceutical Co., Ltd. became the first company that was approved by the CFDA to launch generic Finasteride in China. Later, other companies launched their generic Finasteride products in succession. At the end of 2018, about 20 companies were selling Finasteride in China. The brand-name Finasteride by MSD still took up a market share of more than 90%. The sales value of Finasteride kept rising after the drug was launched in China. In 2017, it reached CNY 248 million, representing a CAGR of about 2.00% from 2013 to 2017.
CRI expects that as the Chinese population ages, the incidence of BPH and the number of patients with BPH increase in China and the indications for Finasteride expand, China’s Finasteride market will continue to grow.

Topics Covered:
– Incidence of benign prostatic hyperplasia in China
– Status of China’s Finasteride market
– Competition on China’s Finasteride market
– Major Finasteride manufacturers in China
– Prices of Finasteride in China
– Major factors influencing the development of China’s Finasteride market
– Prospect of China’s Finasteride market from 2019 to 2023

The post Investigation Report on China’s Finasteride Market, 2019-2023 first appeared on CRI Report.

Investigation Report on China’s Pegaspargase Market, 2019-2023

admin — Wed, 04 Sep 2019 05:31:09 +0000

Description
According to the data released by China’s National Health Commission in Oct. 2018, the incidence of childhood leukemia in Chinese children under 15 is about 4/100,000 to 5/100,000, and the number of childhood leukemia patients under 18 old increases by about 15,000 every year. Childhood leukemia is the second leading cause of death among children under 15 in China. It mainly includes acute leukemia (about 5%), chronic leukemia (3% to 5%) and myelodysplastic syndrome. Acute lymphoblastic leukemia accounts for 70% of childhood leukemia and the cure rate of such leukemia is close to 90%. The other kind of childhood leukemia is acute non-lymphocytic leukemia. The cure rate of acute promyelocytic leukemia in this class has exceeded 90%.
Pegaspargase is an asparaginase preparation that binds Escherichia coli-derived L-asparaginase with polyethylene glycol and lipid bilayer. Compared with L-asparaginase, Pegaspargase retains the bioactivity of asparaginase. Besides, it maintains liposome morphology before accessing tumor tissue, which avoids decomposition by proteinases and extends the half-life of Pegaspargase to (7±2) days. It is a long-acting asparaginase preparation. One-time use of Pegaspargase can replace multiple uses of L-asparaginase, which shortens the period of hospitalization. Pegaspargase is also featured by less immunogenicity and allergic reactions, especially immediate allergic reactions. In terms of other adverse reactions, Pegaspargase is similar to L-asparaginase.
According to CRI, branded Pegaspargase (trade name: Oncaspar) was developed by Enzon Pharmaceuticals, Inc. In 1994, it was approved by the FDA to be applied to those who have acute lymphoblastic leukemia and are allergic to L-asparaginase. In 2000, it was approved by the FDA to be used in the first-line treatment of newly diagnosed leukemia patients. For many reasons, Oncaspar has not been approved to be sold in China. In 2009, the generic Pegaspargase injection developed by Jiangsu Hengrui Medicine Co., Ltd. was approved by the CFDA to be sold in China. By Aug. 2019, only Jiangsu Hengrui Medicine Co., Ltd. has been approved to sell Pegaspargase in China. Other Chinese pharmaceutical companies such as Beijing SL Pharmaceutical Co., Ltd. are also developing generic Pegaspargase. Their Pegaspargase products are expected to be launched in China by 2023.
In China, Pegaspargase is used to treat acute lymphoblastic leukemia. Those who are allergic to natural L-asparaginase can try Pegaspargase. In general, Pegaspargase is used together with other chemotherapy drugs such as vincristine (Oncovin), methotrexate, cytarabine, daunorubicin and pirarubicin. Only when the combined use is confirmed inapplicable will it be used alone. Pegaspargase has proved to have similar curative effect as natural L-asparaginase. It can be used to treat those who are seriously allergic to natural L-asparaginase as well as those who have non-Hodgkin’s lymphoma or acute myeloid leukemia.
According to CRI, the sales value of Pegaspargase kept rising after the drug was launched in China. In 2017, it reached about CNY 74 million, representing a CAGR of 20.10% from 2013 to 2017. As environmental pollution and decoration pollution worsen, the number of leukemia patients in China will keep increasing. Therefore, the market size of Pegaspargase in China will continue to expand from 2019 to 2023. By then, in addition to Aiyang by Jiangsu Hengrui Medicine Co., Ltd., more Pegaspargase products will be approved to be put on the market.

Topics covered:
– Incidence of leukemia in China
– Status of China’s Pegaspargase market
– Retail prices of Pegaspargase in China
– Major factors influencing the development of China’s Pegaspargase market
– Prospect of China’s Pegaspargase market from 2019 to 2023
– Progress of generic Pegaspargase in China

The post Investigation Report on China’s Pegaspargase Market, 2019-2023 first appeared on CRI Report.