There is no complete cure for IBD. The goal of treatment now is primarily to reduce the inflammation that triggers the disease, thereby providing short or long-term relief and reducing the risk of complications. Treatments for IBD usually includes medication and surgery. Medications used for IBD are anti-inflammatory drugs, immunosuppressants, biologics, and antibiotics.

The use of anti-inflammatory drugs is usually the first step in the treatment of IBD. Corticosteroids and amino salicylates (5-ASA) are included in anti-inflammatory drugs, namely Allergan’s Mesalazine, Salix Pharma’s Baisaiazide and Budesonide, and AstraZeneca’s Entocort EC.

Mesalazine, also known as 5-aminosalicylic acid (5-ASA), is an amino salicylic acid anti-inflammatory drug that was originally developed by Ferring and officially launched in the United States in 1985.

Mesalazine can inhibit the synthesis of prostaglandins that cause inflammation and the formation of the inflammatory mediator leukotrienes, thus acting as a significant inhibitor of the inflammation of the intestinal mucosa, especially the connective tissue of the intestinal wall with inflammation. It has good efficacy in ulcerative colitis, ulcerative enteritis and Crohn’s disease.

In 2000, Ferring obtained import registration for its prolonged-release tablets and suppositories for clinical use in China. Subsequently, the sustained-release granules of Ethypharm were marketed in China. Then Dr. Falk Pharma GmbH obtained registration in China for its enema solution, suppositories and enteric coated tablets. After that, generic drugs from local Chinese companies were also marketed one after another.

According to CRI’s market research, the sales value of mesalazine in China grew year-on-year from 2016 to 2019. 2020 saw a slight decline in mesalazine sales value in China due to the COVID-19 outbreak, which affected the proper function of Chinese healthcare facilities, reaching approximately CNY314 million (USD48.2 million), with a CAGR of 7.7% from 2016 to 2020. After years of market competition, in 2020, according to sales value, Ferring’s mesalazine (trade name PENTASA^®) only ranked third in the Chinese market, with the top two occupied by Dr Falk Pharma GmbH and Shanghai Aidefa Pharmaceutical.

It is expected that since the COVID-19 pandemic is under control in China, its mesalazine market will see growth from 2021 to 2025.

Topics Covered:

• Impact of COVID-19 on China’s Mesalazine Market
• Development Environment of Mesalazine in China
• Sales Volume of Mesalazine in China
• Sales Volume and Value of Mesalazine in China by Region
• Major Mesalazine Manufacturers in China and Their Market Shares
• Sales Price of Mesalazine in China
• Prospects of China’s Mesalazine Market, 2021-2025

The post Research Report on China’s Mesalazine Market, 2021-2025 first appeared on CRI Report.

Peptic ulcers and gastrointestinal bleeding are common diseases in China with a large number of patients. Due to the fast pace of modern life, accelerated urbanization and great mental stress, the number of cases is increasing year by year, and the incidence of digestive diseases accounts for 10%-20% of the total Chinese population with extremely high recurrence rate.

There is no significant difference between H2RA and PPIs in the incidence of risk events related to increased gastric acidity and gastrointestinal bleeding, and they can both greatly reduce the costs associated with stress ulcer prophylaxis. Therefore, industry insiders believe that H2RA may be more cost-effective.

Roxatidine is a long-acting H2RA with a stronger-than-ranitidine acid-suppressive effect and a mucosal protective effect. The effective dose of roxatidine is 150 mg/day, which is three to six times more effective than cimetidine and twice as effective as ranitidine. Clinical data show that in the comparison of H2 receptor antagonists for peptic ulcer recurrence rate, the rate is the smallest when using roxatidine.

Roxatidine is a fourth generation H2 receptor blocker and is available in oral and injectable dosage forms.

Roxatidine, originally developed by ASKA Pharmaceutical Co., Ltd, was first marketed in Japan in 1986 in the oral form for the treatment of gastric and duodenal ulcers, Zollinger-Ellison syndrome, reflux esophagitis and gastritis; the injectable form, first marketed in Japan in 1995 for the treatment of upper gastrointestinal bleeding and pre-anesthesia, was one of the few drugs used for peptic ulcers and bleeding in hospitalized patients.

According to CRI’s market research, the roxatidine from the original developer, ASKA Pharmaceutical is not marketed in China. As of August 2021, only two companies, Beijing Sihuan Pharmaceutical and HPGC Bioengineering have obtained the approval for manufacturing roxatidine in the Chinese market, with Beijing Sihuan Pharmaceutical occupies the most market share.

Up till now, the only dosage form of roxatidine available in the Chinese market is injection, and it is expected that oral preparations may be available in the next few years.

According to CRI’s market research, the market size of roxatidine in China kept growing from 2016 to 2020. In 2020, despite the impact of COVID-19, the sales value of roxatidine in the Chinese market increased to CNY428 million (approximately USD65.8 million), with a CAGR of 37.3% from 2016 to 2020.

CRI expects that from 2021 to 2025, the market size of roxatidine in China will continue to grow as the number of patients with digestive diseases in China keep increasing, and the average sales price of roxatidine in China will decrease due to the competitive market while both sales volume and value will continue to rise.

Topics Covered:

• Impact of COVID-19 on China’s Roxatidine Market
• Development Environment of Roxatidine in China
• Sales Volume of Roxatidine in China
• Sales Volume and Value of Roxatidine in China by Region
• Major Roxatidine Manufacturers in China and Their Market Shares
• Sales Price of Roxatidine in China
• Prospects of China’s Roxatidine Market, 2021-2025

The post Research Report on China’s Roxatidine Market, 2021-2025 first appeared on CRI Report.