The anti-cancer mechanism of platinum antitumor drugs can be divided into 4 steps: transmembrane transport, hydration dissociation, targeted migration, and acting on DNA to cause DNA replication disorder, thus inhibiting the division of cancer cells.

According to CRI’s market research, there are five types of platinum-based antitumor drugs commonly used in China: first-generation cisplatin, second-generation carboplatin and nedaplatin, third-generation oxaliplatin and lobaplatin. Lobaplatin, 1,2-diammino-methy lcyclobutane-platinum (II) lactate, was developed in Germany. In 2002, China’s Hainan Changan International Pharmaceutical purchased the patent right and the production and selling rights in China from ASAT, a German company. In 2005, its lobaplatin production was approved by the NMPA of China and marketed as a new Category I drug. In addition to affecting DNA synthesis and replication, its mechanism also affects the expression of the original tumor gene c-mye which is involved in oncogenesis, apoptosis and cell proliferation. The approved indications for lobaplatin in China are advanced breast cancer, small cell lung cancer and chronic myelomonocytic leukemia (CMML).

According to CRI’s market research, since its launch in China, lobaplatin showed an upward trend in sales volume and value from 2005 to 2019. In 2020, the sales value of lobaplatin in China declined to USD472 million due to the outbreak of COVID-19 at the beginning of the year which affected the proper functioning of Chinese healthcare institutions, but the CAGR from 2016 to 2020 was still up to 20.3%.

CRI expects that sales of lobaplatin in China will recover gradually from 2021 to 2025 as the COVID-19 is effectively controlled in the country. And the rising incidence of advanced breast cancer, small cell lung cancer and chronic granulocytic leukemia in China caused by increasing environmental pollution and changing lifestyles will boost the sales of lobaplatin. Generic drugs of lobaplatin are also expected to be available in China in the next few years, which will lower the average sales price of lobaplatin and increase the sales volume.

Topics Covered:

• The Impact of COVID-19 on China’s Lobaplatin Market
• The Incidence of Cancer in China
• The Development Environment of Lobaplatin in China
• Sales Volume of Lobaplatin in China
• Sales Volume and Value of Lobaplatin in China by Region
• Major Lobaplatin Manufacturers in China and Their Market Shares
• Price of Lobaplatin in China’s market
• Prospects of China’s Lobaplatin Market, 2021-2025

The post Research Report on China’s Lobaplatin Market, 2021-2025 first appeared on CRI Report.

Unlike other tumors, breast cancer can also be treated by endocrine therapy beside conventional treatments such as surgery, radiotherapy and chemotherapy. Endocrine therapy is applied to the whole treatment process of breast cancer patients from early adjuvant treatment to postoperative adjuvant treatment and recurrence salvage in clinical practice because it boasts good curative effect and can greatly reduce the risk of cancer coming back. Endocrine therapy for breast cancer is mainly achieved by oral medications.

Drugs for breast cancer endocrine therapy are divided into three categories, estrogen receptor modulators, aromatase inhibitors and estrogen receptor down-regulators. Anastrozole belongs to the second category and is indicated for the treatment of advanced breast cancer in postmenopausal women. Patients who are estrogen receptor negative but tamoxifen positive can take it. Anastrozole is also indicated for the adjuvant treatment of estrogen receptor-positive early-stage breast cancer in postmenopausal women.

Anastrozole was developed by AstraZeneca with Arimidex as its trade name. And it was first marketed in the United States in 1995, approved by the FDA of U.S. for the treatment of advanced breast cancer in postmenopausal women. 1999 saw the introduction of AstraZeneca’s anastrozole into China, where it was approved for use in the adjuvant treatment of estrogen receptor-positive early-stage breast cancer in postmenopausal women. In the following years, generic versions of anastrozole were launched by local Chinese companies. According to CRI’s market research, AstraZeneca still occupied more than 80% of China’s anastrozole market share in 2020 in terms of market value, thus having a huge competitive advantage.

According to CRI’s survey data, the sales value of anastrozole in China kept increasing year by year from 2016 to 2020, not much impacted by COVID-19. In 2020, the sales value of anastrozole in China was about CNY452 million, with a CAGR of 12.1% from 2016 to 2020.

CRI expects that with the rising incidence of breast cancer in China, anastrozole still has significant room for growth in the Chinese market. In addition, compared with other drugs of the same category, anastrozole has been clinically used earlier and is reimbursable under the medical insurance with little cost, and it has relatively fewer side effects as well. Some studies suggest that anastrozole may reduce the risk of invasive estrogen receptor-positive breast cancer and ductal carcinoma in situ in a high-risk postmenopausal breast population. New indications for anastrozole are also expected to be approved in China soon. According to CRI’s estimation, from 2021 to 2025, the sales volume and value of anastrozole in China will continue to grow.

Topics Covered:

• The Impact of COVID-19 on China’s Anastrozole Market
• Development Environment of Anastrozole in China
• Sales Volume of Anastrozole in China
• Sales Volume and Value of Anastrozole in China by Region
• Major Anastrozole Manufacturers in China and Their Market Share
• Sales Price of Anastrozole in China
• Prospects of China’s Anastrozole Market, 2021-2025

The post Research Report on China’s Anastrozole Market, 2021-2025 first appeared on CRI Report.