Breast cancer – CRI Report

Research Report on China’s Exemestane Market, 2021-2025

admin — Fri, 10 Sep 2021 03:01:04 +0000

Breast cancer is a common malignant tumor in menopausal women, and now ranks first among malignant tumors in women. Recently, the number of breast cancer patients in China has been increasing year by year, with 420,000 new cases and 120,000 deaths in China in 2020. Breast cancer has become a malignant tumor that seriously endangers women’s health. Hormone therapy is a widely accepted treatment, especially for the treatment of estrogen receptor positive tumors. Aromatase inhibitors offer a new option for hormone therapy. Exemestane, an irreversible steroidal aromatase inactivator, significantly reduces circulating levels of estrogen in menopausal women by irreversibly binding to the active site of the enzyme and inactivating it, thus achieving an anti-tumor effect.

Exemestane is a third-generation aromatase inhibitor originally developed by Pharmacia & Upjoin (now a subsidiary of Pfizer). It was first approved in the UK in April 1999 and has been marketed in several countries for clinical use in the treatment of advanced breast cancer in postmenopausal women. Exemestane tablets are an effective and selective treatment for postmenopausal hormone-dependent breast cancer. Exemestane tablets, as third-generation aromatase inhibitors, are with strong selectivity and long-lasting effects. They can also control breast cancer growth by inhibiting aromatase and blocking estrogen production.

According to CRI’s market research, Pharmacia & Upjoin’s exemestane was not introduced into the Chinese market until 2008, when several generic drugs from local Chinese companies were already available in the Chinese market, of which the exemestane tablets from Qilu Pharmaceutical was already marketed in China in 2002. Pharmacia &Upjoin’s exemestane (trade name AROMASIN^®) is extremely competitive in the Chinese market, accounting for more than 90% of China’s exemestane market in 2020 in terms of sales value. Despite the impact of the COVID-19 outbreak on the Chinese healthcare industry in early 2020, the sales value of exemestane in the Chinese market continued to grow in 2020, reaching approximately CNY400 million (USD61.6 million), with a CAGR of 9.2% from 2016 to 2020.

Breast cancer has replaced lung cancer as the number one cancer worldwide due to the rapid growth in the number of new cases in 2020. The increasing breast cancer cases are fundamentally caused by the altering risk factors for breast cancer, such as changing lifestyles and notions of marriage and childbearing due to economic growth, namely a general rise in the age of women having children, a decrease in the average number of births, overweight, obesity and lack of exercise, all contributing to the increase in the incidence of breast cancer. CRI expects that from 2021 to 2025, new cases of breast cancer in China will continue to grow, resulting in increases in both sales volume and value of exemestane in the Chinese market.

Topics Covered:

Impact of COVID-19 on China’s Exemestane Market
Development Environment of Exemestane in China
Sales Volume of Exemestane in China
Sales Volume and Value of Exemestane in China by Region
Major Exemestane Manufacturers in China and Their Market Shares
Sales Price of Exemestane in China
Prospects of China’s Exemestane Market, 2021-2025

The post Research Report on China’s Exemestane Market, 2021-2025 first appeared on CRI Report.

Research Report on China’s Lobaplatin Market, 2021-2025

admin — Fri, 10 Sep 2021 03:01:03 +0000

According to IARC of WHO, globally, there were 19.29 million new cases of cancer in 2020, among which 2.26 million were cases of breast cancer, surpassing the 2.2 million cases of lung cancer. Breast cancer has become the most prevalent cancer around the world. For Chinese patients, breast cancer ranks first in the incidence of malignant tumors among women, with about 304,000 cases per year, of which about 3% to 10% of women have distant metastases at the time of diagnosis. Even among early stage patients, 30% to 40% of them can develop into advanced breast cancer. The 5-year survival rate for patients with advanced breast cancer in China is only 20%, and the overall median survival time is 2 to 3 years, which is significantly lower than that in developed countries. the statistics from IARC have also shown that there were 3 million cancer deaths in China in 2020, with 120,000 deaths from breast cancer. The number of new lung cancer cases in China in 2020 reached 820,000, 15%-20% of which were cases of small cell lung cancer. The number of deaths from lung cancer in China in 2020 was up to 710,000, accounting for 23.8% of all cancer deaths. Chronic myelomonocytic leukemia (CMML) is a type of cancer caused by myeloproliferative neoplasm with 1-2 cases per 100,000 people. It accounts for approximately 15% of newly diagnosed adult leukemia cases, and considering that China’s population is upwards of 1.4 billion, the number of new CMML cases would be above 20,000 per year, and the number of surviving CMML patients exceeds 100,000.

The anti-cancer mechanism of platinum antitumor drugs can be divided into 4 steps: transmembrane transport, hydration dissociation, targeted migration, and acting on DNA to cause DNA replication disorder, thus inhibiting the division of cancer cells.

According to CRI’s market research, there are five types of platinum-based antitumor drugs commonly used in China: first-generation cisplatin, second-generation carboplatin and nedaplatin, third-generation oxaliplatin and lobaplatin. Lobaplatin, 1,2-diammino-methy lcyclobutane-platinum (II) lactate, was developed in Germany. In 2002, China’s Hainan Changan International Pharmaceutical purchased the patent right and the production and selling rights in China from ASAT, a German company. In 2005, its lobaplatin production was approved by the NMPA of China and marketed as a new Category I drug. In addition to affecting DNA synthesis and replication, its mechanism also affects the expression of the original tumor gene c-mye which is involved in oncogenesis, apoptosis and cell proliferation. The approved indications for lobaplatin in China are advanced breast cancer, small cell lung cancer and chronic myelomonocytic leukemia (CMML).

According to CRI’s market research, since its launch in China, lobaplatin showed an upward trend in sales volume and value from 2005 to 2019. In 2020, the sales value of lobaplatin in China declined to USD472 million due to the outbreak of COVID-19 at the beginning of the year which affected the proper functioning of Chinese healthcare institutions, but the CAGR from 2016 to 2020 was still up to 20.3%.

CRI expects that sales of lobaplatin in China will recover gradually from 2021 to 2025 as the COVID-19 is effectively controlled in the country. And the rising incidence of advanced breast cancer, small cell lung cancer and chronic granulocytic leukemia in China caused by increasing environmental pollution and changing lifestyles will boost the sales of lobaplatin. Generic drugs of lobaplatin are also expected to be available in China in the next few years, which will lower the average sales price of lobaplatin and increase the sales volume.

Topics Covered:

The Impact of COVID-19 on China’s Lobaplatin Market
The Incidence of Cancer in China
The Development Environment of Lobaplatin in China
Sales Volume of Lobaplatin in China
Sales Volume and Value of Lobaplatin in China by Region
Major Lobaplatin Manufacturers in China and Their Market Shares
Price of Lobaplatin in China’s market
Prospects of China’s Lobaplatin Market, 2021-2025

The post Research Report on China’s Lobaplatin Market, 2021-2025 first appeared on CRI Report.

Research Report on China’s Anastrozole Market, 2021-2025

admin — Fri, 10 Sep 2021 03:01:03 +0000

According to IARC’s 2020 World Cancer Report, the number of new cases of breast cancer reached 2.26 million in 2020, larger than that of lung cancer cases which was 2.2 million. Breast cancer has become the most prevalent cancer around the world. In China, there were 420,000 new cases of breast cancer in 2020. According to the statistics, the incidence of breast cancer in China continues to rise, growing twice as fast as the global average rate, ranking first in the world. And Chinese women develop breast cancer at much younger ages, which are 10 years earlier than women in Western countries.

Unlike other tumors, breast cancer can also be treated by endocrine therapy beside conventional treatments such as surgery, radiotherapy and chemotherapy. Endocrine therapy is applied to the whole treatment process of breast cancer patients from early adjuvant treatment to postoperative adjuvant treatment and recurrence salvage in clinical practice because it boasts good curative effect and can greatly reduce the risk of cancer coming back. Endocrine therapy for breast cancer is mainly achieved by oral medications.

Drugs for breast cancer endocrine therapy are divided into three categories, estrogen receptor modulators, aromatase inhibitors and estrogen receptor down-regulators. Anastrozole belongs to the second category and is indicated for the treatment of advanced breast cancer in postmenopausal women. Patients who are estrogen receptor negative but tamoxifen positive can take it. Anastrozole is also indicated for the adjuvant treatment of estrogen receptor-positive early-stage breast cancer in postmenopausal women.

Anastrozole was developed by AstraZeneca with Arimidex as its trade name. And it was first marketed in the United States in 1995, approved by the FDA of U.S. for the treatment of advanced breast cancer in postmenopausal women. 1999 saw the introduction of AstraZeneca’s anastrozole into China, where it was approved for use in the adjuvant treatment of estrogen receptor-positive early-stage breast cancer in postmenopausal women. In the following years, generic versions of anastrozole were launched by local Chinese companies. According to CRI’s market research, AstraZeneca still occupied more than 80% of China’s anastrozole market share in 2020 in terms of market value, thus having a huge competitive advantage.

According to CRI’s survey data, the sales value of anastrozole in China kept increasing year by year from 2016 to 2020, not much impacted by COVID-19. In 2020, the sales value of anastrozole in China was about CNY452 million, with a CAGR of 12.1% from 2016 to 2020.

CRI expects that with the rising incidence of breast cancer in China, anastrozole still has significant room for growth in the Chinese market. In addition, compared with other drugs of the same category, anastrozole has been clinically used earlier and is reimbursable under the medical insurance with little cost, and it has relatively fewer side effects as well. Some studies suggest that anastrozole may reduce the risk of invasive estrogen receptor-positive breast cancer and ductal carcinoma in situ in a high-risk postmenopausal breast population. New indications for anastrozole are also expected to be approved in China soon. According to CRI’s estimation, from 2021 to 2025, the sales volume and value of anastrozole in China will continue to grow.

Topics Covered:

The Impact of COVID-19 on China’s Anastrozole Market
Development Environment of Anastrozole in China
Sales Volume of Anastrozole in China
Sales Volume and Value of Anastrozole in China by Region
Major Anastrozole Manufacturers in China and Their Market Share
Sales Price of Anastrozole in China
Prospects of China’s Anastrozole Market, 2021-2025

The post Research Report on China’s Anastrozole Market, 2021-2025 first appeared on CRI Report.

Investigation Report on China’s Capecitabine Market 2021-2025

admin — Mon, 19 Jul 2021 02:43:41 +0000

Capecitabine is a pyrimidine analog (pentoxycarbonyl-deoxy-cytosine nucleoside) that has anti-tumor activity to inhibit a variety of solid tumors, including breast and colon cancer. Capecitabine was developed by Roche. Its product, XELODA was approved to enter the Chinese market in 2001. By 2020, there are several manufacturers in the Capecitabine market in China.

According to CRI’s market research, the sales of Capecitabine in the Chinese market increased year by year from 2016 to 2019. Due to the impact of the COVID-19 pandemic on the hospital’s overall diagnosis and treatment services, sales in 2020 decreased to CNY 914 million, a year-on-year decrease of 9.31%. The CAGR of Capecitabine sales in the Chinese market from 2016 to 2020 is 1.21%.

CRI expects that with the easing of the COVID-19 pandemic, the sales of Capecitabine in the Chinese market will have a restorative growth in 2021-2025. In 2020, the number of COVID-19 breast cancers worldwide reached 2.26 million, and the number of colon cancers reached 1.93 million, both of which were on the rise. The number of breast and colon cancers in China will be also on the rise in the future. Therefore, the sales volume of Capecitabine, which is used to inhibit the anti-tumor activity of a variety of solid tumors, will increase with the increase in the number of breast cancer and colon cancer patients in China. There is also room for sales to rise. In addition, by the end of 2020, a number of companies led by Chengdu Yuandong Biopharmaceuticals have already reported for Capecitabine generic drug approval. In the next few years, more manufacturers will join the Chinese market. The sales volume and sales of Capecitabine in China are expected to rise.

Topics Covered:

-The impact of COVID-19 on China’s Capecitabine market
– Sales value of China’s Capecitabine 2016-2020
– Competitive landscape of China’s Capecitabine market
– Prices of Capecitabine in China
– Prices of Capecitabine in China by regions and manufacturers
– Analysis on factors affecting the development of China’s Capecitabine market
– Prospect of China’s Capecitabine market from 2021 to 2025

The post Investigation Report on China’s Capecitabine Market 2021-2025 first appeared on CRI Report.